Note1

.doc
School
Swinburne University of Technology **We aren't endorsed by this school
Course
MDA 10001
Subject
Nursing
Date
Nov 15, 2023
Pages
2
Uploaded by MinisterWalrusMaster975 on coursehero.com
Warnings/Precautions Concerns related to adverse events: • CNS depression: May cause CNS depression, which may impair physical or mental abilities; patients must be cautioned about performing tasks that require mental alertness (eg, operating machinery or driving). • Hepatotoxicity: [U.S. Boxed Warning]: Acetaminophen may cause severe hepatotoxicity, potentially requiring liver transplant or resulting in death; hepatotoxicity is usually associated with excessive acetaminophen intake (>4 g/day). Risk is increased with alcohol use (eg, ≥3 drinks per day), preexisting liver disease, and intake of more than one source of acetaminophen-containing medications. Chronic daily dosing in adults has also resulted in liver damage in some patients. • Hypersensitivity: Hypersensitivity and anaphylactic reactions have been reported with acetaminophen use; discontinue immediately if symptoms of allergic or hypersensitivity reactions occur. • Skin reactions: Rarely, acetaminophen may cause serious and potentially fatal skin reactions such as acute generalized exanthematous pustulosis, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Discontinue treatment if severe skin reactions develop. Disease-related concerns: • Cardiovascular disease: Use is contraindicated in cardiovascular or cerebrovascular insufficiency (eg, recent MI, stroke), hypertension, organic heart disease, and peripheral vascular disease. • G6PD deficiency: Use with caution in patients with known G6PD deficiency; rare reports of hemolysis have occurred with acetaminophen use. • Hepatic impairment: Use is contraindicated in patients with hepatic disease. • Renal impairment: Use is contraindicated in patients with severe renal disease. Other warning/precautions: • Dosage limit: Limit acetaminophen dose from all sources (prescription, OTC) ≤4 g/day (adults).
Generic Equivalent Available: US May be product dependent
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