28 Feb 2023: UPSC Exam Comprehensive News Analysis TABLE OF CONTENTS A. GS 1 Related B. GS 2 Related C. GS 3 Related SCIENCE AND TECHNOLOGY 1.'Organ on a chip': a tech which mimics disease systems in laboratory conditions D. GS 4 Related E. Editorials ENVIRONMENT AND ECOLOGY 1. Unpacking the new set of e-waste rules INTERNATIONAL RELATIONS 1. The New START treaty on pause F. Prelims Facts 1. National Science Day 2. Section 126 of Representation of the People Act of 1951 3. Hindustan 228-201 LW aircraft G. Tidbits 1. 1,300-year-old Buddhist stupa found in Odisha's Jajpur 2.U.K., EU start 'new chapter' over N. Ireland trade pact H. UPSC Prelims Practice Questions I. UPSC Mains Practice Questions
A. GS 1 Related Nothing here for today!!! B. GS 2 Related Nothing here for today!!! C. GS 3 Related Category: SCIENCE AND TECHNOLOGY 1. 'Organ on a chip': a tech which mimics disease systems in laboratory conditions Syllabus: Science and Technology- developments and their applications and effects in everyday life. Prelims: Organ on a chip technology Mains: Key issues associated with the existing procedure for introducing a new drug and the significance and advantages of using Organ on a chip technology Context The passage of the Food and Drug Administration Modernization Act 2.0 by the US government in December 2022 is expected to provide momentum to the R&D of "organ chips". Organ chips or Organ on a chip model • Organ chips are small devices with human cells that are used to mimic the environment in human organs such as blood flow and breathing movements, that can act as synthetic environments to test new drugs. • Such chips are translucent which helps provide a window for researchers to look into the inner workings of the organ being studied. • Donald Ingber, a professor of bioengineering and director of the Wyss Institute at Harvard University along with his colleagues developed the first human organ-on-a-chip model in 2010. o This first organ-on-a-chip model was a "lung on a chip" that resembled the biochemical aspects of the lung and its breathing mechanism. • Later in 2014, members of the Wyss Institute started a startup named "Emulate Inc." to commercialise the organ-on-a-chip technology.
• This group of researchers at Emulate Inc have created various such different chips which include that of the epithelial barrier, bone marrow, kidney, gut, vagina and liver. Benefits and significance of Organ chips Image Source: pubs.rsc.org
Uploaded by ElderKnowledgeGrouse28 on coursehero.com